23andMe® brings the world of genetics to you. 23andMe analyzes variations at specific positions in your genome. These variations, called SNPs (Single Nucleotide Polymorphisms), have the potential to tell you about your ancestry, your traits—such as eye or hair color—and certain health conditions.
The 23andMe Health + Ancestry Service includes:
- Carrier Status Reports
- Genetic Health Risk Reports
- Wellness Reports
- Traits Reports
- Ancestry Composition Report
- Haplogroup Reports
- Neanderthal Ancestry Report
- Your DNA Family Report
- DNA Relatives Tool
- Additional Tools and Features
The 23andMe Carrier Status* reports are included in the Health + Ancestry Service. The 23andMe Carrier Status reports tell you about variants that may not affect your health, but could affect the health of your future family. Being a "carrier" means you "carry" one genetic variant for a condition. Carriers do not typically have the genetic condition, but they can pass a genetic variant down to their children. Understanding your carrier status helps you work with your doctor to prepare for the health of your future family.
The 23andMe Genetic Health Risk* reports are included in the Health + Ancestry Service. The 23andMe Genetic Health Risk reports tell you if you have genetic variants associated with an increased risk of developing certain health conditions - such as Late-Onset Alzheimer's Disease* or Parkinson's Disease*. While having a particular variant can be linked to a higher risk for a condition, it does not necessarily mean you will develop the condition. It is important to remember that these reports do not cover all possible genetic variants that could influence risk for these conditions and that other non-genetic factors, such as environment and lifestyle, can also influence risk for these conditions.
The 23andMe Wellness reports are included in the Health + Ancestry Service. The 23andMe Wellness reports can help you make more informed choices that may relate to healthy living. Find out how your DNA may influence your caffeine consumption, lactose digestion and your muscle type.
The 23andMe Traits reports are included in the Health + Ancestry Service. Our Traits reports are a fun way to explore how your DNA makes you unique, from your food preferences to physical features.
This report uses DNA you inherited from both sides of your family and tells you the proportion of your DNA that comes from each of 45 worldwide genetic populations**, offering a detailed view of your ancestry from before ocean-crossing ships and airplanes were on the scene. The report also compares your DNA to individuals of known ancestry from over 115 countries and territories in Europe, Africa, the Americas, Asia, and Oceania, telling you more about where your recent ancestors may have lived.
These reports tell you about the ancient origins of your matrilineal and patrilineal ancestors. Haplogroups are assigned by finding the genetic variants that are unique to each group. These genetic variants typically originated tens of thousands of years ago. Women and men both receive Maternal Haplogroup report based on their mitochondrial DNA; men also receive a Paternal Haplogroup report based on their Y chromosomes.
Note: Your matrilineal ancestors include your mother, her mother, her mother's mother, etc., and your patrilineal ancestors include your father, his father, his father's father, etc.
Even though Neanderthals vanished about 40,000 years ago, their DNA lives on in us. Based on research, Neanderthals interbred with humans around 60,000 years ago. Our Neanderthal Ancestry feature will tell you how much of your ancestry can be traced back to Neanderthals using SNPs located across all of your autosomes and your X chromosome(s).
The 23andMe Your DNA Family report tells you about the diverse group of 23andMe customers who have DNA in common with you and how many of these DNA Relatives you have around the world. After viewing this report, you can connect with your genetic relatives in the DNA Relatives tool.
The 23andMe DNA Relatives tool requires customers to opt-in to the feature to access it. This is a popular, interactive tool that allows you to find and connect with genetic relatives and see specific DNA segments you share with them. The DNA Relatives tool can identify relatives on any branch of your recent family tree by taking advantage of the autosomal chromosomes—the 22 chromosomes that are passed down from your ancestors on both sides of your family—and the X chromosome.
The Health + Ancestry Service also includes:
- Access to your raw, uninterpreted genetic data file*** (Must not be used for medical or diagnostic purposes). Learn more.
- Access to share, compare and discover more with friends and family. Allowing you to trace DNA through your close family and explore the genetic similarities and differences between you and family members.
*The 23andMe PGS test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child's risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. For important information and limitations regarding each genetic health risk and carrier status report, visit https://www.23andme.com/test-info/. The Late-onset Alzheimer’s Disease genetic health risk report is indicated for reporting of the ε4 variant in the APOE gene and describes if a person has a variant associated with an increased risk of developing late-onset Alzheimer’s disease. The ε4 variant included in this report is found and has been studied in many ethnicities. Detailed risk estimates have been studied the most in people of European descent. The Parkinson’s Disease genetic health risk report is indicated for reporting of the G2019S variant in the LRRK2 gene, and the N370S variant in the GBA gene and describes if a person has variants associated with an increased risk of developing Parkinson’s disease. The variants included in this report are most common and best studied in people of European, Ashkenazi Jewish, and North African Berber descent.
**Customers genotyped on version 5 (v5) of our genotyping chip will receive 45 populations worldwide and 115 recent ancestor locations. We are working to support this update with adding new African and East Asian regional populations for customers who received results and were processed on a previous version of our genotyping chip. Current customers can check their account settings to learn the version of the genotyping chip used to process his or her data.
***This data has undergone a general quality review however only a subset of markers have been individually validated for accuracy. The data from 23andMe’s Browse Raw Data feature is suitable only for informational use and not for medical, diagnostic or other use. Consult with a healthcare professional before making any major lifestyle changes.