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Understanding Genetic Risk Factor Reports

In the Genetic Risk Factor section, you will find information about how your genetics influences risk for complex diseases. Each report covers common genetic variants associated with specific diseases, and will inform you whether or not you possess the genetic variant associated with that disease.

Please know that the Genetics Risk Factor reports do not take into account personal or family history or your lifestyle or environment. There may also be additional genetic factors, yet unidentified or unavailable to our technology, that also contribute to risk for these conditions.

It is also important to keep in mind that our tests do not diagnose any health conditions. If you are concerned about something you learned from your reports or if you are worried about your personal or family history, you should contact your physician or other medical professional, such as a genetic counselor.

This article will discuss the following topics:

How do I opt in to locked reports?

Reports for certain health conditions are not readily displayed with your genetic information results. This is because these particular reports are thought to contain more sensitive information. For this reason, we leave it up to the customers to decide if they wish to view their results. We encourage you to speak with your healthcare provider or a genetic counselor should you wish to learn more or need help deciding if finding out this information is right for you.

These opt in reports are marked by a lock icon, and can be previewed without revealing your results. Before you can view your results for the below reports, you must first opt-in. Everyone, regardless of whether or not they have a variant associated with that condition, must view a disclaimer prior to unlocking each report. The disclaimer can be found under the Your Results section on each of these reports:

Once you have unlocked a locked report, it will reorder itself alphabetically within the Genetic Risk Factor reports list. You will not have the ability to hide, or lock, the individual report once it has been unlocked.

How are my results displayed?

Each Genetic Risk Factor report includes a Your Results table, and all possible genetic outcomes will be displayed. Because all genetic outcomes are displayed, it is important to note that the Genetic Result for each person is located directly across from the corresponding profile name in the table.

If you are sharing with other users, you can choose to view the results of all of your connections by selecting “Show results for all profiles” from the drop-down menu. Alternatively, if you only want to view the results for the profiles in your account, select “Show results for my profiles only.”

How ethnicity can impact results?

Many of the Genetic Risk Factor reports provide information in the context of ethnicity. This is because some variants are more common in a particular ethnicity, and some associations between variants and conditions are better studied in certain populations. Thus, some reports are most applicable to people of a particular ethnic background.

We do not use your self-reported ethnicity information to compute your ancestry composition.

What does a “no-call” mean?

In some cases, we are not able to provide a result for a particular report. If results cannot be provided for a report, you will see “no call”. If you are seeing this result, our algorithm was not able to confidently determine your genotype (genetic makeup) at that particular site. All genetic markers used in our reports are evaluated for high data quality and accuracy. Occasionally, a person's data may not allow us to determine his or her genotype confidently at a particular marker. Some “no call” variants are expected, especially in the raw data, and are not a cause for concern.

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